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15. TYPICAL FORMS OF PATHOLOGY OF THE WHITE BLOOD CELL SYSTEM. LEUKOCYTOSIS AND LEUCOPENIA. LEUKEMOID REACTIONS

I. Choose the set of leukocytes which is predominantly found in the peripheral blood of healthy people.

1. Neutrophils, monocytes, lymphocytes, eosinophils, basophils.

2. Neutrophils, promonocytes, lymphocytes, eosinophils, basophils.

3. Neutrophils, promyelocytes, lymphocytes, eosinophils, basophils.

4. Neutrophils, metamyelocytes, lymphocytes, eosinophils, basophils.

II. Leukocytosis may result from the following:

1. Increased release from the storage pool in the marrow.

2. Demargination of neutrophils.

3. Decreased extravasation of leukocytes into tissues.

4. Expansion of marrow leukocyte precursor pool.

5. Splenomegaly.

6. Increased peripheral use of leukocytes.

7. Suppression of myeloid stem cells.

III. Leukopenia may result from the following:

1. Insufficiency of vitamin B12.

2. Splenomegaly.

3. Overwhelming bacterial, fungal or rickettsial infections.

4. Aplastic anemia.

5. Strenuous physical exercise.

6. Antimetabolites used in cancer treatment.

7. Tissue necrosis such as myocardial infarction or burns.

8. Increased production of erythropoietin.

IV. Typical signs of regenerative leukocytosis are:

1. Nuclear shift to the left.

2. Nuclear shift to the right.

3. Increased number of leukocytes in the blood.

4. Increased number of reticulocytes.

5. Increased hematocrit.

V. Mechanisms of redistribution of leukocytosis are:

1. Increased release of leukocytes from the marrow storage pool.

2. Expansion of the marrow precursor pool.

3. An increase in the peripheral blood marginating pool.

4. An increase in the peripheral blood circulating pool.

5. Decreased extravasation of leukocytes into tissues.

6. Hypersmotic dehydration.

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